蔡仁，教授，毕业于美国佛罗里达大学，获分析化学博士学位，师从谭蔚泓教授。目前，主要从事分子检测、分子医学和生物传感器等研究。在生物分子检测，疾病诊疗和生物传感器领域，发表SCI学术论文90余篇，其中包括在J. Am. Chem. Soc.，Anal. Chem.等国际顶级学术期刊发表第一作者或通讯作者论文60余篇，相关研究成果被C&EN等知名媒体报道。获国家级青年人才项目和国家自然科学基金项目支持。入选Nanoscale杂志2024 Emerging Investigator。另外，兼任Collagen and Leather杂志青年编委。

Email：cairen@hnu.edu.cn

2019.4—2019.10 Visiting scholar, University of Florida, USA

2019.1—2019.3 Postdoc, Pacific Northwest National Laboratory (PNNL), USA

2018.10—2019.1 Visiting scholar, Center for Soft and Living Materials, Institute for Basic Science, South Korea

2018.1—2018.12 Postdoc, University of Florida, USA

2011.8—2013.8 Research assistant, Nanyang Technological University, Singapore

2013—2017 PhD, Department of Chemistry, University of Florida, USA

发表论文：

[1]Kangfu Chen, Hongfen Yang,* Ren Cai.* Microfluidics for Nanomedicine Delivery. ACS Biomaterials Science & Engineering 2024, Accepted.

[2]Suping Deng, Futing Wang, Yujin Li, Jingxian Li, Jiajun Zhan, Yan Shen, Ziyang Peng, Chang-xiao Song, Ren Cai,* Hongfen Yang,* Weihong Tan. Triple helix molecular switch cascade multiple signal amplification strategies for ultra-sensitive chloramphenicol detection. Anal. Chem. 2024, 96, 51, 20312-20317.

[3]Jing Xu, Yujin Li, Futing Wang, Xinqi Luo, Wei Zhang, Yifan Lyu, Hongfen Yang, Ren Cai,* Weihong Tan. On-demand controlled bidirectional DNAzyme path for ultra-sensitive heavy metal ion detection. Chem. Sci. 2024, 15, 18170 - 18178.

[4]Ziyang Peng, Jingxian Li, Shi Xiang, Yan Yang, Futing Wang, Hongfen Yang,* Ren Cai,* Weihong Tan. Novel Ternary System for Electrochemiluminescence Biosensor and Application toward Pb2+ Assay. ACS Appl. Mater. Interfaces 2024, 16, 42, 56902-56909.

[5]Jing Xu, Yujin Li, Futing Wang, Hongfen Yang,* Kejing Huang, Ren Cai,* Weihong Tan. A smartphone mediated “all in one” biosensing chip for visual and value-assisted detection. Anal. Chem. 2024, 96, 39, 15780-15788.

[6]Jiajun Zhan, Futing Wang, Yujin Li, Jingxian Li, Shi Xiang, Yan Yang, Kangfu Chen,* Hongfen Yang,* Ren Cai.* A triple signal amplification strategy for accurate and ultra-sensitive miRNA-21 detection. Anal. Chem. 2024, 96, 36, 14464-14470.

[7]Yan Shen, Futing Wang, Yujin Li, Jingxian Li, Shi Xiang, Yan Yang, Hongfen Yang,* Ren Cai,* Weihong Tan. Novel self-powered biosensor based on Au nanoparticles @ Pd nanorings and catalytic hairpin assembly for ultrasensitive miRNA-21 assay. Anal. Chem. 2024, 96, 36, 14508-14515.

[8]Jia Ge, Zhiyao Zhai, Yuru Chen,* Zhaohui Li,* Hongfen Yang, Ren Cai.* Nitrogen-doped MoS2 QDs as fluorescent probes for sensitive detection of curcumin and cell imaging. Analytica Chimica Acta 2024, 1325, 343090.

[9]Shi Xiang, Jingxian Li, Futing Wang, Yan Yang, Hongfen Yang,* Ren Cai,* Weihong Tan. Ultrasensitive Electrochemiluminescence Biosensing Platform Based on Novel Polymer Dots with Aggregation-induced Emission for Dual Biotoxins Assay. ACS Appl. Mater. Interfaces 2024, 16, 37748-37756.

[10]Jingxian Li, Hongfen Yang,* Ren Cai,* Weihong Tan. Novel Nucleic Acid-Assisted Ion-Responsive ECL Biosensor based on Hollow AuAg Nanoboxes with Excellent SPR and Effective Co-Reaction Acceleration. Anal. Chem. 2024, 96, 27, 11076-11082.

[11]Yan Yang, Jingxian Li, Shi Xiang, Futing Wang, Hongfen Yang,* Ren Cai,* Weihong Tan. PdPt@SnS2 Nanosheets for a Novel Ultra-Sensitive Electrochemiluminescence Biosensor for miRNA-21 Assay. Anal. Chem. 2024, 96, 23, 9653-9658.

[12]Futing Wang, Chunxiao Zhang, Suping Deng, Yifei Jiang, Penghui Zhang, Hongfen Yang,* Li Xiang,* Yifan Lyu, Ren Cai,* Weihong Tan. Dual-responsive 3D DNA nanomachines cascaded hybridization chain reactions for novel self-powered flexible microRNA-detecting platform. Biosensors and Bioelectronics 2024, 252, 116149.

[13]Yujin Li, Jing Xu,* Yangyang Hou, Jianqi Lu, Ke-jing Huang,* Ren Cai.* 3D hierarchically electrode combined with DNA circuit strategy powered highly sensitive and portable sensing devices. Sensors and Actuators B: Chemical 2024, 401, 134963.

[14]Yujin Li, Jing Xu,* Xinqi Luo, Futing Wang, Zhong Dong, Ke-jing Huang,* Chengjie Hu, Mengyi Hou, Ren Cai.* Novel Hollow MoS2@C@Cu2S Heterostructures for High Zinc Storage Performance. Nanoscales 2024, 16, 657-663.（Nanoscale 2024 Emerging Investigator）

[15]Futing Wang, Peng Wang, Hongfen Yang,* Ren Cai,* Weihong Tan. Self-powered biosensing system with multivariate signal amplification for real-time amplified detection of PDGF-BB. Anal. Chem. 2023, 95, 44, 16359-16365.

[16]Shi Xiang, Jingxian Li, Futing Wang, Hongfen Yang,* Yifei Jiang, Penghui Zhang, Ren Cai,* Weihong Tan. Novel Ultralow-Potential Electrochemiluminescence Aptasensor for the Highly-Sensitive Detection of Zearalenone Using a Resonance Energy Transfer System. Anal. Chem. 2023, 95, 40, 15125-15132.

[17]Yan Yang, Futing Wang, Jingxian Li, Shuoyao He, Yifan Lyu, Hongfen Yang,* Ren Cai,* Weihong Tan. Self-Powered Biosensor based on DNA Walkers for Ultrasensitive MicroRNA Detection. Anal. Chem. 2023, 95, 40, 15042-15048.

[18]Jingxian Li, Mengyu Luo, Hongfen Yang,* Ren Cai,* Weihong Tan. AuPt Nanodonuts as a Novel Co-Reaction Accelerator and Luminophore for Label-Free Electrochemiluminescence Aptasensor. Anal. Chem. 2023, 95, 37, 13838-13843.

[19]Shi Xiang, Jingxian Li, Muling Shi, Hongfen Yang,* Ren Cai,* Weihong Tan. A Novel ECL Aptasensor for Ultra-Highly Sensitive Detection of Patulin based on Terbium Organic Gels as Co-reaction Accelerator in a 3, 4, 9, 10-perylenetetracarboxylic Acid/K2S2O8 System. Sensors and Actuators B: Chemical 2023, 394, 134365.

[20]Mengyu Luo, Xianyu Zhu, Hongfen Yang, Liang Yan,* Ren Cai,* Yuliang Zhao, Weihong Tan. Fabrication of AuPt Heterostructured Nanorings for Enhanced Synergistic Radio-Photothermal Therapy. Nano Today 2023, 51, 101919.  

[21]Futing Wang, Ren Cai,* Weihong Tan. Self-Powered Biosensor for a Highly Efficient and Ultrasensitive Dual-Biomarker Assay. Anal. Chem. 2023, 95, 14, 6046-6052.

[22]Futing Wang, Hongfen Yang,* Jinwei Wu, Yifan Lyu, Kejing Huang,* Ren Cai,* Weihong Tan. An “On-Off” self-powered biosensor via GOD activated signal transduction for ultrasensitive detection of multiple biomarkers. Chemical Engineering Journal 2023, 468, 143732.

[23]Xing Li, Hongfen Yang,* Shaorong Lu,* Ren Cai.* A flexible strain sensor with high electrical conductivity, rapid electrothermal response, and high strain sensitivity for real-time monitoring of human joint movement. Advanced Materials Technologies 2023, 8, 2300079.

[24]Demiao Ma, Jia Ge,* Ang Wang, Jingxian Li, Hongfen Yang, Wenlei Zhai,* Ren Cai.* Ultrasensitive determination of a-glucosidase activity using CoOOH nanozymes and its application to inhibitor screening. Journal of Materials Chemistry B, 2023, 11, 2727-2732.

[25]Jingxian Li, Song Wang, Hongfen Yang,* Run Li,* Ren Cai,* Weihong Tan. An “off-on” electrochemical luminescence biosensor with aggregation-induced emission for ultrasensitive detection of aflatoxin B1. Sensors and Actuators B: Chemical 2023, 380, 133407.

[26]Chengyi Hong, Lingling Chen, Jiayi Huang, Yunling Shen, Hongfen Yang, Zhiyong Huang, Ren Cai,* Weihong Tan. Gold nanoparticle-decorated MoSe2 nanosheets as highly effective peroxidase-like nanozymes for total antioxidant capacity assay. Nano Research 2023, 16, 7180-7186 .

[27]Fu-Ting Wang, Yang-Yang Hou, Xuecai Tan, Ke-Jing Huang,* Jing Xu,* Ren Cai.* Real-time multiple signal amplification self-powered biosensing platform for ultrasensitive detection of MicroRNA. Biosensors and Bioelectronics 2023, 222, 114933.

[28]Jingxian Li, Hongfen Yang,* Ren Cai,* Weihong Tan. Ultra-Highly Sensitive Sandwich-Type Electrochemical Immunosensor for Selective Detection of Tumor Biomarkers. ACS Appl. Mater. Interfaces 2022, 14, 39, 44222-44227.

[29]Chengyi Hong, Dandan Li, Siying Cao, Xin Huang, Hongfen Yang,* Dan Yang, Zhiyong Huang, Ren Cai,* Weihong Tan. Sensitive and multicolor detection of nitrite based on iodide-mediated etching of gold nanostars. Chem. Commun. 2022, 58, 12983-12986.

[30]Jingxian Li, Ren Cai,* Weihong Tan. A Novel ECL Sensing System for Ultrahigh Sensitivity miRNA-21 Detection based on Catalytic Hairpin Assembly Cascade Nonmetallic SPR Effect. Anal. Chem. 2022, 94, 36, 12280-12285.

[31]Zuocai Zhang, Tianyun Lu, Dan Yang, Shaorong Lu,* Ren Cai,* Weihong Tan. A Dual-function Sensor for Highly Sensitive Detection of Flame and Humidity. Small 2022, 18, 38, 2203334.

[32]Jingxian Li, Mengyu Luo, Hongfen Yang, Chao Ma, Ren Cai,* Weihong Tan. Novel Dual-Signal Electrochemiluminescence Aptasensor Involving the Resonance Energy Transform System for Kanamycin Detection. Anal. Chem. 2022, 94, 16, 6410-6416.

[33]Yadong Yang, Sujie Yang, Shudong Jiang, Mengru Liu, Xiuyu Liu, Gang Tang,* Ren Cai,* Weihong Tan. Facile synthesis of zinc-containing mesoporous silicate from iron tailings and enhanced fire retardancy of rigid polyurethane foam. Macromol. Mater. Eng. 2022, 307, 11, 2200586.

[34]Jia Ge, Demiao Ma, Guohang Duan, Zhongyue Yan, Like Yang, Dan Yang, Ren Cai,* Weihong Tan. A novel probe for tetracyclines detection and its applications in cell imaging based on fluorescent WS2 quantum dots. Analytica Chimica Acta 2022, 1221, 340130.

[35]Chengyi Hong, Jingjing Wang, Yuying Wang, Zhiyong Huang, Hongfen Yang,* Dan Yang, Ren Cai,* Weihong Tan. Fluorescence detection of milk allergen β-lactoglobulin based on aptamer and WS2 nanosheets. J. Mater. Chem. B 2022, 10, 6752-6757.

[36]Jingxian Li, Mengyu Luo, Can Jin, Penghui Zhang, Hongfen Yang,* Ren Cai,* Weihong Tan. Plasmon-Enhanced Electrochemiluminescence of PTP Decorated Eu-MOF-Based Pt-Tipped Au Bimetallic Nanorods for Lincomycin Assay. ACS Appl. Mater. Interfaces 2022, 14, 1, 383-389.

[37]Hao Fu, Dan Yang, Di Qiu, Chun-Hua Yan, Ren Cai,* Yaping Du,* Weihong Tan. Highly Stable 3D Supercuboids to 2D ZnSe Nanosheets: Forming for A High-Efficient Catalysis System. J. Phys. Chem. Lett. 2022, 13, 1855-1862.

[38]Zuocai Zhang, Tianyun Lu, Dan Yang,* Shaorong Lu,* Ren Cai,* Weihong Tan. A high-wet-strength biofilm for readable and highly sensitive humidity sensors. Nano Lett. 2021, 21, 21, 9030-9037.

[39]Kuo Liu, Dan Yang,* Hongfen Yang,* Shaorong Lu,* Ren Cai,* Weihong Tan. Multifunctional shape memory films for a flexible electrical sensor. Macromol. Mater. Eng. 2021, 306, 12, 2100580.

[40]Ren Cai, Huandong Xiang, Dan Yang, Keng-Te Lin, Yuanzheng Wu, Ruyi Zhou, Zhanjun Gu, Liang Yan,* Yuliang Zhao,* Weihong Tan.* Plasmonic AuPt@CuS heterostructure with enhanced synergistic efficacy for radiophotothermal therapy. J. Am. Chem. Soc. 2021, 143, 39, 16113-16127.

[41]Chengyi Hong, Lingling Chen, Chenyue Wu, Dan Yang, Jia-Yong Dai, Zhiyong Huang, Ren Cai,* Weihong Tan. Green synthesis of Au@WSe2 hybrid nanostructures with the enhanced peroxidase-like activity for sensitive colorimetric detection of glucose. Nano Research 2022, 15, 1587-1592.

[42]Zuocai Zhang, Dan Yang, Shaorong Lu,* Ren Cai,* Weihong Tan. Rapid Water-responsive Shape Memory Films for Smart Resistive Bending Sensors. Nano Today 2021, 38, 101202.

[43]Chengyi Hong, Xiaoxia Zhang, Sishi Ye, Hongfen Yang,* Zhiyong Huang,* Dan Yang,* Ren Cai,* Weihong Tan. Aptamer-Pendant DNA Tetrahedron Nanostructure Probe for Ultrasensitive Detection of Tetracycline by Coupling Target-Triggered Rolling Circle Amplification. ACS Appl. Mater. Interfaces 2021, 13, 17, 19695-19700.

[44]Zuocai Zhang, Dan Yang, Hongfen Yang, Yuqi Li, Shaorong Lu,* Ren Cai,* Weihong Tan. A hydrophobic sisal cellulose microcrystal film for fire alarm sensors. Nano Lett. 2021, 21, 5, 2104-2110.

[45]Jia Ge, Jian-Hua Yu, Hongfen Yang,* Dan Yang,* Ren Cai.* Human serum albumin templated MnO2 nanosheets as an efficient biomimetic oxidase for biomolecule sensing. J. Mater. Chem. B 2020, 8, 11090-11095.

[46]Chengyi Hong, Xiaoxia Zhang, Chenyue Wu, Qin Chen, Hongfen Yang,* Dan Yang,* Zhiyong Huang, Ren Cai,* Weihong Tan.* On-Site Colorimetric Detection of Cholesterol Based on Polypyrrole Nanoparticles. ACS Appl. Mater. Interfaces 2020, 12 (49), 54426-54432.

[47]Jia Ge, Yun Hu, Ruijie Deng, Zhaohui Li, Kaixiang Zhang, Muling Shi, Dan Yang,* Ren Cai,* Weihong Tan.* Highly sensitive microRNA detection by coupling nicking-enhanced rolling circle amplification with MoS2 quantum dots. Anal. Chem. 2020, 92, 19, 13588-13594.

[48]Ren Cai, Haiyan Jin, Dan Yang, Keng-Te Lin, Jianke Sun, Zhuo Chen, Xiaobing Zhang, Weihong Tan.* Generalized Preparation of Au NP@Ni(OH)2 Yolk-Shell Nanoparticles and Their Superior Catalytical Activity for Oxygen Evolution Reaction. Nano Energy 2020, 104542.

[49]Ren Cai, Dan Yang, Xigao Chen, Yifan Lyv, He Zhen, Kangfu Chen, Yu Yang, Liqin Zhang, Jia Ge, Lian Xia, Yuliang Zhao, Weihong Tan.* 3D Halos Assembled from Fe3O4/Au NPs with Enhanced Catalytic and Optical Properties. Nanoscale 2019, 11 (43), 20968-20976.

[50]Ren Cai, Yaping Du, Dan Yang, Guohua Jia, Bowen Zhu, Yifan Lyu, Liping Qiu, Xigao Chen, Dechao Chen, Wei Chen, Liqin Zhang, Meng Luo,Lu Yang, Yuliang Zhao, Weihong Tan.* Free-standing 2D nanorafts by assembly of 1D nanorods for biomolecule sensing. Nanoscale 2019, 11, 12169-12176.

[51]Ren Cai, Dan Yang, Yifan Lyu, Bowen Zhu, Zhen He, Yusuke Kitamura, Liping Qiu, Xigao Chen, Yuliang Zhao, Zhuo Chen,* Weihong Tan.* Generalized preparation of 2D quasi-nanosheets via self-assembly of nanoparticles. J. Am. Chem. Soc. 2019, 141, 1725-1734.

[52]Ren Cai, Dan Yang, Liang Yan, Feng Tian, Jichao Zhang, Yifan Lyv, Kangfu Chen, Chengyi Hong, Xigao Chen, Yuliang Zhao, Zhuo Chen, Weihong Tan.* Free-floating 2D Nanosheets With Superlattice Assembled From Fe3O4 Nanoparticles. ACS Appl. Nano Mater. 2018, 1 (10), 5389-5395.

[53]J. Ge,# Ren Cai,# L. Yang, L. Zhang, Y. Jiang, Y. Yang, C. Cui, S. Wan, X. Chu, Weihong Tan.* Core-Shell HA-Au NPs@Si NPs Nanoprobe for Sensitive Fluorescence Hyaluronidase Detection and Cell Imaging. ACS Sustain. Chem. Eng. 2018, 6 (12), 16555-16562.

[54]Ren Cai, D. Yang, X. Chen, Y. Huang, Y. Lyv, J. He, M. Shi, I-T. Teng, S. Wan, W. Hou, Weihong Tan.* Three Dimensional Multipod Superstructure based on Cu(OH)2 as a Highly Efficient Nanozyme. J. Mater. Chem. B 2016, 4, 4657-4661.

[55]Ren Cai, D. Yang, L. Zhang, J. Wu, X. Chen, Z. Zhang, H. Huo, Q. Yan, Weihong Tan.* Fabrication of ultrathin Zn(OH)2 nanosheets as drug carriers. Nano Research 2016, 9, 2520-2530.

[56]Ren Cai, D. Yang, L. Zhang, L. Qiu, H. Liang, X. Chen, Z. Zhang, S. Cansiz, S. Wan, Q. Yan, Weihong Tan.* A facile process for the preparation of three-dimensional (3D) hollow Zn(OH)2 nanoflowers at room temperature. Chem. Eur. J. 2016, 22(32), 11143-11147.

[57]Ren Cai, D. Yang, S. Peng, X. Chen, Y. Huang, Y. Liu, W. Hou, S. Yang, Z. Liu, Weihong Tan.* Single Nanoparticle to 3D Supercage: Framing for an Artificial Enzyme System. J. Am. Chem. Soc. 2015, 137, 13957-13963. (C&EN NEWS, http://cen.acs.org/articles/93/web/2015/10/Tiny-Boxes-Hold-Catalytic-Surprise.html).

[58]Ren Cai, Y. Du, S. Peng, H. Bi, W. Zhang, D. Yang, J. Chen, T. M. Lim, H. Zhang, Q. Yan.* The Synthesis of Porous Metal MCO3 (M=Mn, Co, Ca) Hollow Microstructures and Adsorption Property Thereof. Chem. Eur. J. 2014, 20(2), 421-425.

[59]Ren Cai, J. Chen, D. Yang, Z. Zeng, S. Peng, J. Wu, W. Zhang, C. Zhu, T. -M. Lim, H. Zhang, Q. Yan.* Solvothermal-induced Conversion of One-Dimensional Multi-layer Nanotubes to Two-Dimensional Hydrophilic VOx Nanosheets: Synthesis and Water Treatment Application. ACS Appl. Mater. Interfaces 2013, 5(20), 10389-10394.

[60]Ren Cai, Y. Du, W. Zhang, H. Tan, T. Zeng, X. Huang, H. Yang, C. Chen, H. Liu, J. Zhu, S. Peng, J. Chen, Y. Zhao, H. Wu, Y. Huang, R. Xu, T. -M. Lim, Q. Zhang, H. Zhang, Q. Yan.* Synthesis of Porous Amorphous FePO4 Nanotubes and Their Li Storage Properties. Chem. Eur. J. 2013, 19(5), 1568-1572.

[61]Ren Cai, H. Li, W. Zhang, H. Tan, D. Yang, H. H. Hng, T. M. Lim, Q. Yan.* Controlled Synthesis of Double-wall a-FePO4 Nanotubes and Their LIB Cathode Properties. Small 2013, 9(7), 1036-1041.

[62]Ren Cai, J. Chen, J. Zhu, C. Xu, W. Zhang, C. Zhang, W. Shi, H. Tan, D. Yang, H. H. Hng, T. M. Lim, Q. Yan.* Synthesis of CuxS/Cu Nanotubes and Their Lithium Storage Properties. J. Phys. Chem. C 2012, 116 (23), 12468-12474.

[1]National Young Talent Program

[2]Nanoscale，Emerging Investigator