湖南大学，生命医学交叉研究院，教授，博士生导师

研究方向：

一、肺发育与损伤修复

肺发育主要分为两个阶段：早期分支发育形成各级肺支气管，以及肺泡发育来构建气体交换单位。当受到损伤时，成熟健康的呼吸系统会通过修复来替代有缺陷或死亡的细胞。发育和修复的异常会引起呼吸功能受损及肺部疾病。肺是我们呼吸的唯一器官，研究肺的发育和损伤修复对我们了解肺部疾病的发生、发展，以及寻找有效的治疗手段异常重要。课题组主要利用条件性基因敲除小鼠以及损伤模型小鼠来研究肺泡发育、肺泡损伤修复以及肺泡相关疾病。具体研究方向主要集中在：

1）研究肺的分支发育、肺泡发育、及肺泡损伤修复过程中细胞命运的决定因素；

2）探索肺泡形成的分子和细胞生物学机制；

3）利用不同的小鼠肺损伤模型研究肺泡的各种组成细胞在修复和再生过程中的作用；

4）利用小鼠遗传模型和3D培养模型来研究慢性阻塞性肺病(COPD)、间质性肺病(ILD)等疾病的发生、发展过程。

二、线粒体的生物合成及异质性分布在肺及其他器官中的作用

线粒体是几乎所有细胞生命活动的能量来源，然而线粒体在不同类型细胞中的定位存在异质性。线粒体是如何感知细胞内环境的各种信号，从而进行生物合成以及迁移到细胞的主要需能部位也是我们研究的重点。

邮箱：zhangk2024@hnu.edu.cn

2024-07—今，湖南大学生命医学交叉研究院，教授

2020-08—2024-06，加州大学旧金山分校(UCSF)，科研助理

2015-08—2020-07，加州大学旧金山分校(UCSF)，博士后

2010-09—2015-06，武汉大学，细胞生物学，硕博连读

2006-09—2010-07，山东农业大学，生物技术，本科

[1]Zhang K,Yao E,Aung T,Chuang PT.The alveolus:our current knowledge of how to build the gas exchange unit in the lung.Current Topics in Developmental Biology.2024;159:59-129.

[2]Zhang K,Aung T,Yao E,Chuang PT.Lung patterning:is a distal-to-proximal gradient of cell allocation and fate decision a general paradigm?BioEssays.2023 Nov 27:e2300083.

[3]Zhang K,Yao E,Chuang E,Chen B,Chuang EY,Chuang PT.mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung by modulating mitochondrial capacity.Nature Communications.2022 Nov 25;13(1):7252.

[4]Zhang K,Yao E,Chuang E,Chen B,Chuang EY,Volk RF,Hofmann KL,Zaro B,Chuang PT.Wnt5a–Vangl1/2 signaling regulates the position and direction of lung branching through the cytoskeleton and focal adhesion.PLOS Biology.2022 Aug 26;20(8):e3001759.

[5]Zhang K,Yao E,Wang SA,Chuang E,Wong J,Minichiello L,Schroeder A,Eckalbar W,Wolters P,Chuang PT.A functional circuit formed by the autonomic nerves and myofibroblasts controls mammalian alveolar formation for gas exchange.Developmental Cell.2022 Jul 11;57(13):1566-1581.e7.(Highlighted by Developmental Cell:https://www.cell.com/developmental-cell/fulltext/S1534-5807(22)00453-1).

[6]Zhang K,Yao E,Chen B,Chuang E,Wong J,Seed R,Nishimura S,Wolters P,Chuang PT.Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria.eLife.2022;11:e68598.(Highlighted by eLife:https://elifesciences.org/articles/79651).

[7]Zhang K,Yao E,Lin C,Chou YT,Wong J,Li J,Wolters P,Chuang PT.A mammalian Wnt5a–Ror2–Vangl2 axis controls the cytoskeleton and confers cellular properties required for alveologenesis.eLife.2020;9:e53688.(Recommended by“Faculty of 1000”https://facultyopinions.com/prime/737939869).

[8]Tang J#,Zhang K#,Dong J,Yan C,Hu C,Ji H,Chen L,Chen S,Zhao H,Song Z.Sam50-Mic19-Mic60 axis determines mitochondrial cristae architecture by mediating mitochondrial outer and inner membrane contact.Cell Death&Differentiation.2020 Jan;27(1):146-160.PMCID:PMC31097788(#co-first author).

[9]Zhang K,Li H,Song Z.Membrane depolarization activates the mitochondrial protease OMA1 by stimulating self-cleavage.EMBO Reports.2014 May;15(5):576-85.PMCID:PMC24719224.

其他已发表的成果

[1]Wang SA,Wu YC,Yang FM,Hsu FL,Zhang K,Hung JJ.NCI677397 targeting USP24-mediated induction of lipid peroxidation induces ferroptosis in drug-resistant cancer cells.Molecular Oncology.2023 Dec 22.PMID:38140768.

[2]Yao E,Lin C,Wu Q,Zhang K,Song H,Chuang PT.Notch Signaling Controls Transdifferentiation of Pulmonary Neuroendocrine Cells in Response to Lung Injury.Stem Cells.2018 Mar;36(3):377-391.

[3]Lin C,Yao Y,Zhang K,Jiang X,Croll S,Thompson-Peer K,Chuang PT.YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis.eLife.2017 Mar 21;6.pii:e21130.

[4]Song H,Lin C,Yao E,Zhang K,Li X,Wu Q,Chuang PT.Selective ablation of tumor suppressors in parafollicular C cells elicits medullary thyroid carcinoma.J Biol Chem.2017 Jan 24;292(9):3888-3899.

[5]Li H,Ruan Y,Zhang K,Jian F,Hu C,Miao L,Gong L,Sun L,Zhang X,Chen S,Chen H,Liu D,Song Z.Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization.Cell Death&Differentiation.2016 Mar;23(3):380-92.PMCID:PMC5072434.

[6]Ruan Y,Li H,Zhang K,Jian F,Tang J,Song Z.Loss of Yme1L perturbates mitochondrial dynamics.Cell Death&Disease.2013 Oct 31;4:e896.PMCID:PMC3920928.