涂海军，博士、湖南大学教授、博士生导师、岳麓学者，湖南省芙蓉学者奖励计划特聘教授。2011年1月-2015年6月先后在法国巴黎高师/法国国家健康与医药研究院（Ecole Normale Supérieure, Paris/INSERM,U1024）和法国国家科学研究中心/克洛德·贝尔纳里昂第一大学(University Claude Bernard Lyon 1,CNRS, UMR5534)从事博士后研究工作；2009年6月-2010年5月在法国国家科学研究中心功能基因组研究所（L’Institut de Génomique Fonctionnelle, IGF-CNRS）与法国巴黎高师从事访问学者研究；2008年7月-2012年12月任华中科技大学分子生物物理教育部重点实验室讲师；2008年获华中科技大学生物物理学博士学位。研究和阐释了细胞外基质蛋白Punctin调控胆碱能和GABA能突触后结构域的特化的分子与遗传机制（Nature,2014; Neuron,2015）；揭示了“神经肌肉接头-运动肌肉-肠上皮”跨组织细胞信号轴调控肠道天然免疫的细胞机制（PNAS,2021）；提出了肠道“神经元-平滑肌-肠上皮”神经免疫单元调控肠道天然免疫的新观点（Immunity,2023）。以第一或者通讯作者已在Nature, Immunity, Neuron, PNAS, Molecular & Cellular Proteomics, Frotiers in Immunology等国际学术期刊上发表SCI收录论文多篇。2015年获法国科学院生物科学进步奖，2020年聘为湖南省芙蓉学者奖励计划特聘教授，2022年荣获湖南省教育教学成果一等奖。主持国家自然基金项目、国家重点研发计划子课题、外国专家引进项目、湖南省重点领域研发计划项目、湖南省自然科学基金，校企产学研联合研发等多项研究与开发项目。

联系方式：haijuntu@hnu.edu.cn

2013.07 - 2015.06，博士后研究员, University Claude Bernard Lyon1, CGphiMC UMR CNRS 5534, Lyon, France

2011.01 - 2013.06，博士后, IBENS. INSERM U1024. Ecole Normale Supérieure, Paris, France

2009.06 - 2009.11，访问学者, IGF - CNRS, Montpellier, France

2008.07 - 2013.12，讲师,华中科技大学分子生物物理学教育部重点实验室,武汉,湖北

2005.03 - 2008.03，博士,华中科技大学生命科学与技术学院，神经生物物理学

2001.09 - 2004.07，硕士，武汉大学生命科学学院，分子病毒学

[1]国家重点研发计划项目子课题（2021YFA0910003）

[2]高端外国专家引进计划（G2021160024L，G2022160021L，G2023160021L）

[3]“一带一路”创新人才交流外国专家项目（DL2023160002L）

[4]国家自然科学基金委面上项目（31671048,32471242）

[5]国家自然科学基金委应急管理项目（31540020）

[6]国家自然科学基金委青年基金项目（30800197）

[7]湖南省重点领域研发计划项目（2020SK2092）

[8]湖南省自然科学基金面上项目（2021JJ30098,2017JJ2041）

发表论文：

[1]Bérangère Pinan-Lucarré*, Haijun Tu*, Marie Pierron, Janet E. Richmond and Jean-Louis Bessereau#. C. elegans Punctin specifies cholinergic versus GABAergic identity of postsynaptic domains. Nature, 2014, 511(7510):466-70. (Highlighted in the Editors’ choice Section of Science Signaling. Recommended article by Faculty of 1000 ).（IF=69.50,一区）

[2]Haijun Tu*, Bérangère Pinan-Lucarré*, Tingting Ji, Maelle Jospin and Jean-Louis Bessereau#. C. elegans Punctin clusters GABAA receptors via neuroligin binding and UNC 40/DCC recruitment. Neuron, 86(6),1406-1419, July 17, 2015. (Previewed at Neuron, 2015,86(6): 1321-1324, June 17, 2015; Recommended article by Faculty of 1000.).（IF=18.69,一区）

[3]Junqiang Liu*, Pei Zhang*, Zhongfan Zheng*, Muhammad Irfan Afridi*, Shan Zhang, Zhiqing Wan, Xiumei Zhang, Lukas Stingelin, Yirong Wang and Haijun Tu#. GABAergic signaling between enteric neurons and intestinal smooth muscle promotes innate immunity and gut defense in Caenorhabditis elegans, Immunity (2023), https://doi.org/10.1016/j.immuni.2023.06.004.（IF=32.40,一区）

[4]Zhongfan Zheng*, Xiumei Zhang*, Junqiang Liu*, Ping He*, Shan Zhang, Jie Gao, Yongning Zhang, Shengmei Yang, Na Kang, Muhammad Irfan Afridi, Shangbang Gao, Chunhong Chen, and Haijun Tu#. GABAergic Synapse Suppresses Intestinal Innate Immunity via Insulin Signalling. 2021, PNAS, (Online: https://www.pnas.org/content/118/20/e2021063118)（IF=12.78,一区）

[5]Zhongfan Zheng*, Yilixiati Aihemaiti*, Junqiang Liu*, Muhammad Irfan Afridi, Xiumei Zhang, Shengmei Yang, Yongfu Xu, Chunhong Chen, and Haijun Tu#, The bZIP transcription factor ZIP-11 is required for the innate immune regulation, Frontiers in Immunology, 2021, DOI: 10.3389/fimmu.2021.744454（IF=8.78,一区）

[6]Wei Jiang, Pei Zhang, Peng Yang, Na Kang, Junqiang liu, Yilixiati Aihemaiti, Haijun Tu#, Phosphoproteome Analysis of Acute Ischemic Hippocampus Identifies Potassium Voltage-gated Channel KCNQ2 Interacting with Annexin A6 Alleviates Synaptotagmin1-mediated Ischemic Neuron Injury. Molecular & Cellular Proteomics, 2022 doi: https://doi.org/10.1016/j.mcpro.2022.100222.（IF=7.38,一区）

[7]Chao Liu*, Wei Jiang*, Xibin Tian*, Peng Yang, Le Xiao, Jianglin Li, Liping Qiu, Haijun Tu#, and Weihong Tan#. Identification of Vigilin as a potential ischemia biomarker by Brain Slice-based SELEX. Analytical Chemistry, 2019, 91, 6675 - 6681.（IF=8.01,一区）

[8]Haijun Tu*, Chanjuan Xu*, Wenhua Zhang, Qiuyao Liu, Philippe Rondard,Jean-Philippe Pin#, and Jianfeng Liu#. GABAB Receptor Activation ProtectsNeurons from Apoptosis via IGF-1 Receptor Transactivation, Journal of Neuroscience. 2010,30: 749-759.（IF=6.71,一区）

[9]Ming Lei*, Yanheng Tan*, Jingyi Ke, Mengqi Wang, Zeyang He, Guangshuo Ou, Haijun Tu#, Weihong Tan#. Loss of Cilia in Chemosensory Neurons Inhibits Pathogen Avoidance in Caenorhabditis elegans. Microbes and Infection. (IF=5.8,一区)

[10]Ming Lei*, Yanheng Tan*, Haijun Tu#, Weihong Tan#. Neuronal Basis and Diverse Mechanisms of Pathogen Avoidance in Caenorhabditis elegans. Frontiers in Immunology. DOI: 10.3389/fimmu.2024.1353747（IF=7.30,一区）

[11]Xibin Tian*, Wuyan Yang*, Wei Jiang*, Zhen Zhang, Junqiang Liu, Haijun Tu#. Multi-omics profiling identifies microglial Annexin A2 as a key mediator of NF-κB pro-inflammatory signaling in ischemic reperfusion injury. Mol Cell Proteomics. 2024; 23(2): 100723.（IF=7.38,一区）

[12]Junqiang Liu,* Ming Lei*, Mengqi Wang, Shu Chen, Haijun Tu#. Protocol for survival assay of Caenorhabditis elegans to Pseudomonas aeruginosa PA14 infection. STAR Protocols. 2024. doi:10.1016/j.xpro.2024.103070

[13]Junqiang Liu*, Pei Zhang*, Zhongfan Zheng*, Muhammad Irfan Afridi*, Shan Zhang, Zhiqing Wan, Xiumei Zhang, Lukas Stingelin, Yirong Wang, Haijun Tu#. GABAergic signaling between enteric neurons and intestinal smooth muscle promotes innate immunity and gut defense in Caenorhabditis elegans. Immunity. 2023; 56(7): 1515-1532.e9.（IF=32.40,一区）

[14]Xiumei Zhang*, Yirong Wang*, Zixin Cai*, Zhiqing Wan, Yilixiati Aihemaiti, Haijun Tu#. A gonadal gap junction INX-14/Notch GLP-1 signaling axis suppresses gut defense through an intestinal lysosome pathway. Front Immunol. 2023; 14: 1249436.（IF=7.30,一区）

[15]Muhammad Irfan Afridi*, Zhongfan Zheng*, Junqiang Liu*, Lijuan Liu*, Shan Zhang, Zhaozhong Zhu, Yousong Peng, Desheng Zhou, Haijun Tu#. The bZIP transcription factor BATF3/ZIP-10 suppresses innate immunity by attenuating PMK-1/p38 signaling, International immunology. 2023; 35(4): 181-196.（IF=4.40,二区）

[16]Wei Jiang, Pei Zhang, Peng Yang, Na Kang, Junqiang liu, Yilixiati Aihemaiti, Haijun Tu#. Phosphoproteome Analysis of Acute Ischemic Hippocampus Identifies Potassium Voltage-gated Channel KCNQ2 Interacting with Annexin A6 Alleviates Synaptotagmin1-mediated Ischemic Neuron Injury. Molecular & Cellular Proteomics. 2022; 21(5): 100222.（IF=7.38,一区）

[17]Dan Zhu*, Zheming Cao*, Xiaoyang Pang*, Wei Jiang*, Chihao Li, Xing Zhang, Xibin Tian, Haijun Tu#, Panfeng Wu#, Hemin Nie#. Derivation of Stem Cell-like Cells From Spherical Culture of Astrocytes for Enhanced Neural Repair After Middle Cerebral Artery Occlusion. Frontiers in Bioengineering and Biotechnology. 2022; 10: 875514.（IF=6.06,一区）

[18]Zebo Huang#, Long Ma, Ajay Mishra, Jeremy E Turnbull, Haijun Tu#. C. elegans as an emerging model of pharmacological innovation. Frontiers in Pharmacology. 2022; 13: 1029752.（IF=5.98,二区）

[19]Muhammad Irfan Afridi*, Zhongfan Zheng*, Junqiang Liu*, Lijuan Liu*, Shan Zhang, Zhaozhong Zhu, Yousong Peng, Desheng Zhou#, Haijun Tu#. The bZIP Transcription Factor BATF3/ZIP-10 Suppresses Innate Immunity by Attenuating PMK-1/p38 Signaling. International Immunology. 2022, dxac053.（IF=5.07,二区）

[20]Shuting Xie*, Ke Min, Hai Li, Ying Wang, Mincong Liu, Ming Ma, Desheng Zhou#, Haijun Tu#, Bo Chen#. pH as a Key Factor for the Quality Assurance of the Preparation of Gastrodiae Rhizoma Formula Granules. Molecules. 2022; 27(22): 8091.（IF=4.92,二区）

[21]Jiayu Wu*, Shengmei Yang*, Junqiang Liu*, Zhongfan Zheng*, Ming Lei, Pei Zhang, Lukas Stingelin, Jinjun Chen#, Lizhi Xiong#, Haijun Tu#. GABAergic Neuromuscular Junction Suppresses Intestinal Defense of Caenorhabditis elegans by Attenuating Muscular Oxidative Phosphorylation. ACS Chem Neurosci. 2022; 13(23): 3427-3437.（IF=5.78,二区）

[22]Zhongfan Zheng*, Xiumei Zhang*, Junqiang Liu*, Ping He*, Shan Zhang, Jie Gao, Yongning Zhang, Shengmei Yang, Na Kang, Muhammad Irfan Afridi, Shangbang Gao, Chunhong Chen, and Haijun Tu#. GABAergic Synapse Suppresses Intestinal Innate Immunity via Insulin Signalling. 2021, PNAS, (Online: https://www.pnas.org/content/118/20/e2021063118)（IF=12.78,一区）

[23]Chunhong Chen*, Huiyuan Fu*, Ping He, Peng Yang, Haijun Tu#, Extracellular Matrix Muscle Arm Development Defective Protein Cooperates with the One Immunoglobulin Domain Protein to Suppress Precocious Synaptic Remodeling, ACS Chem Neurosci. 2021, 12, 11, 2045–2056（IF=5.78,一区）

[24]Wei Jiang*, Lukas Stingelin*, Pei Zhang*, XibinTian, Na Kang, Junqiang Liu, Yilixiati Aihemaiti, Desheng Zhou#, Haijun Tu#. Enolase2 and enolase1 cooperate against neuronal injury in stroke model. Neuroscience Letters, 2021, 747, 135662.（IF=3.046,三区）

[25]Zhongfan Zheng*, Yilixiati Aihemaiti*, Junqiang Liu*, Muhammad Irfan Afridi, Xiumei Zhang, Shengmei Yang, Yongfu Xu, Chunhong Chen, and Haijun Tu#, The bZIP transcription factor ZIP-11 is required for the innate immune regulation, Frontiers in Immunology, 2021, DOI: 10.3389/fimmu.2021.744454（IF=8.78,一区）

[26]贺娉,康娜,娄萍萍,涂海军#.秀丽隐杆线虫对不同氧浓度的应答及其调控机制研究进展[J].生理学报, 2020, 72(03): 407-417.

[27]Chao Liu*, Wei Jiang*, Xibin Tian*, Peng Yang, Le Xiao, Jianglin Li, Liping Qiu, Haijun Tu#, and Weihong Tan#. Identification of Vigilin as a potential ischemia biomarker by Brain Slice-based SELEX. Analytical Chemistry, 2019, 91, 6675 - 6681.（IF=8.01,一区）

[28]Wei Jiang*, Xibin Tian*, Peng Yang*, Jianglin Li, Le Xiao, Junqiang Liu, Chao Liu, Weihong Tan, Haijun Tu#, Enolase1 alleviates cerebral ischemia-induced neuronal injury via its enzymatic product Phosphoenolpyruvate. ACS Chem Neurosci. 2019, 10, 2877-2889（IF=5.78,一区）

[29]张秀妹,高洁,陈春红,涂海军#.秀丽隐杆线虫固有免疫功能神经调控机制研究进展[J].遗传, 2018, 40(12): 1066-1074.

[30]Haijun Tu*, Bérangère Pinan-Lucarré*, Tingting Ji, Maelle Jospin and Jean-Louis Bessereau#. C. elegans Punctin clusters GABAA receptors via neuroligin binding and UNC 40/DCC recruitment. Neuron, 86(6),1406-1419, July 17, 2015. (Previewed at Neuron, 2015,86(6): 1321-1324, June 17, 2015; Recommended article by Faculty of 1000.).（IF=18.69,一区）

[31]Wenhua Zhang*, Chanjuan Xu*, Haijun Tu*, Yunyun Wang, Qian Sun, Ping Hu,Yongjian Hu, Philippe Rondard, Jianfeng Liu#. GABAB receptor upregulates fragileX mental retardation protein expression in neurons. Scientific Reports, 2015, 5, 10468.（IF=5.228,二区）

[32]Bérangère Pinan-Lucarré*, Haijun Tu*, Marie Pierron, Janet E. Richmond and Jean-Louis Bessereau#. C. elegans Punctin specifies cholinergic versus GABAergic identity of postsynaptic domains. Nature, 2014, 511(7510):466-70. (Highlighted in the Editors’ choice Section of Science Signaling. Recommended article by Faculty of 1000 ).（IF=69.50,一区）

[33]Haijun Tu*, Chanjuan Xu*, Wenhua Zhang, Qiuyao Liu, Philippe Rondard,Jean-Philippe Pin#, and Jianfeng Liu#. GABAB Receptor Activation ProtectsNeurons from Apoptosis via IGF-1 Receptor Transactivation, Journal of Neuroscience. 2010,30: 749-759.（IF=6.71,一区）

[34]Haijun Tu*, Philippe Rondard*, Chanjuan Xu, Federica Bertaso, Fangli Cao,Xueying Zhang, Jean-Philippe Pin, Jianfeng Liu#, Dominant role of GABAB2 andGβγ for GABAB receptor mediated - ERK1/2 /CREB pathway in cerebellar neurons.Cellular Signaling, 2007, 19, 1996-2002. (IF= 4.85，二区)

[35]Philippe Rondard*, Siluo Huang*, Carine Monnier, Haijun Tu, BertrandBlanchard, Nadia Oueslati, Fanny Malhaire, Ying Li, Damien Maurel, GillesLabesse, Jean-Philippe Pin# & Jianfeng Liu#，Functioning of the dimeric GABABreceptor extracellular domain revealed by glycan wedge scanning. EMBO Journal, 2008, 27(9):1321-1332. (IF=14.01，一区)

[36]Carine Monnier, Haijun Tu, Emmanuel Bourrier, Claire Vol, Laurent Lamarque,Eric Trinquet, Jean-Philippe Pin#, and Philippe Rondard#,Trans-activation between 7TM domains: implication in heterodimeric GABAB receptor activation,EMBO Journal, 2011, 30(1):32-42. (IF=14.01，一区)

[37]Guillaume A Baloucoune*, Lei Chun*, Wenhua Zhang*, Chanjuan Xu, SiluoHuang, Qian Sun, Yunyun Wang, Haijun Tu, and Jianfeng Liu#. GABAB receptorsubunit GB1 at the cell surface independently activates ERK1/2 through IGF-1Rtransactivation. PLoS One. 2012;7(6):e39698. (IF=3.75，二区)

[38]Yuxiu Zou*, Siqi Huang, Yixin Liao, Xupeng Zhu, Yiqin Chen, Long Chen, Fang Liu, Xiaoxiao Hu, Haijun Tu, Liang Zhang, Zhangkun Liu, Zhuo Chen#, Weihong Tan. Isotopic graphene-isolated-Au-nanocrystals with cellular Raman-silent signals for cancer cell pattern recognition. Chemical Science. 2018; 9(10): 2842-2849. (IF=8.1，一区)

[39]Chao Liu*, Zike Huang, Wei Jiang, Xiaojing Liu, Jin Li, Xiaoyan Han, Haijun Tu, Liping Qiu#, Weihong Tan#. Programmable pH-Responsive DNA Nanosensors for Imaging Exocytosis and Retrieval of Synaptic Vesicles. Analytical Chemistry. 2020; 92(5): 3620-3626. (IF=8.0，一区)

[40]Yunyun Wang*, Siyu Gai*, Wenhua Zhang, Xuetao Huang, Shumin Ma, Yujia Huo, Yichen Wu, Haijun Tu, Jean-Philippe Pin, Philippe Rondard, Chanjuan Xu#, Jianfeng Liu#. The GABAB receptor mediates neuroprotection by coupling to G13. Science Signaling. 2021; 14(705): eaaz4112. (IF=9.71，一区)

发明专利：

[1]谭蔚泓，涂海军，刘超，蒋伟，发明专利号：CN201811487690.2

[2]涂海军，杨朋，刘军强，发明专利号：ZL201910642115.3

[3]涂海军，娄萍萍，贺娉，实用新型专利号：ZL202220577475.7

[4]涂海军，施洋，杨婷婷，发明专利号：202410298246.5

[5]涂海军，吴嘉誉，谭砚桁，施洋，申请专利号：202410131707X

[1]2022，湖南大学岳麓学者 晨星A岗

[2]2021，国家海外高层次人才计划青年项目入选者