湖南大学二级教授，博士生导师，现任湖南大学研究生院副院长兼学位办主任，生物大分子化学生物学湖南省重点实验室主任

长期从事生命分析化学基础研究，紧密围绕生物医学中关键机制研究的需求，系统性开展生物分子工具创建及其生命分析应用基础研究。近年以通讯作者在Nat. Chem. Biol., J. Am. Chem. Soc.(2), Angew. Chem. Int. Ed.(12)，Science Advances, Nano Lett.(2)等高水平期刊发表学术论文100多篇，出版个人专著2章，授权国家发明专利7项，主持国家自然科学基金重点项目、杰出青年科学基金项目、优秀青年科学基金项目，以及国家重点研发计划项目、课题等。担任中国化学会理事、青年化学工作者委员会副主任委员、英国皇家化学会《RSC Advances》副主编（2015-2022）、《分析化学》编委，入选教育部CJ学者青年学者、WR计划QN拔尖人才等高层次人才计划，获药明康德生命化学研究奖学者奖、中国化学会青年化学奖、卢嘉锡优秀导师奖、湖南省优秀科技工作者、湖南省优秀研究生导师等奖励荣誉，作为主要成员获得湖南省科学技术创新团队奖、湖南省高等教育教学成果一等奖。

联系方式：niezhou@hnu.edu.cn; niezhou.hnu@gmail.com

2019.10 - 至今，湖南大学研究生院副院长兼学位办主任

2015.11 - 2019.10，湖南大学化学化工学院副院长

2011.11 - 2012.11，Purdue University，公派博士后

2011.01 - 至今，湖南大学化学化工学院，教授

2008.06 - 2010.12，湖南大学化学化工学院，副教授

2008.08 - 2008.06，湖南大学化学化工学院，讲师

2002.09 - 2007.07，中科院化学所，化学，博士

1998.09 - 2002.06，南开大学，生物化学，理学学士

主持国家自然科学基金重点项目、杰出青年科学基金项目、优秀青年科学基金项目，以及国家重点研发计划项目、课题等。

发表论文：

[1]S. Yang, M. Wang, D. Tian, X. Zhang, K. Cui, S. Lü, H.-H. Wang, M. Long, Z. Nie*. DNA-functionalized artificial mechanoreceptor for de novo force-responsive signaling. Nat. Chem. Biol., 2024, 20, 1066.

[2]K. Wang, S. Liu, S. Zhou, A. Qileng, D. Wang, Y. Liu, C. Chen, C. Lei*, Z. Nie*. Ligand-responsive artificial protein-protein communication for field-deployable cell-free biosensing. Angew. Chem. Int. Ed., 2024, e202416671 (Very Important Paper)

[3]X. Xie , H. Nan, J. Peng, K. Zeng, H.-H. Wang*, Y. Huang*, Z. Nie*. Hydrogen Sulfide-Triggered Artificial DNAzyme Switches for Precise Manipulation of Cellular Functions. Angew. Chem. Int. Ed., 2024, 63, e202410380. (Very Important Paper)

[4]W. Kang, F. Xiao, X. Zhu, X. Ling, S. Xie, R. Li, P. Yu, L. Cao, C. Lei*, Y. Qiu, T. Liu, Z. Nie*. Engineering anti-CRISPR proteins to create CRISPR-Cas protein switches for activatable genome editing and viral protease detection. Angew. Chem. Int. Ed., 2024, 63, e20240599.

[5]F. He, M. Wang, J. Wang, H-.H. Wang, Z. Nie*. An extracellular miRNA-responsive artificial receptor via dynamic DNA nano-assembly for biomarker-driven therapy. Angew. Chem. Int. Ed., 2023, 62, e202305227. (Very Important Paper)

[6]R. Tang, Y. Fu, B. Gong, Y.-Y. Fang, H.-H. Wang, Y. Huang, Z. Nie*. P. Wei*. A chimeric conjugate of antibody and programmable DNA nanoassembly smartly activates T cells for precise cancer cell targeting. Angew. Chem. Int. Ed., 2022, 61, e202205902.

[7]M. Wang, D. Yang, Q Lu, L. Liu, Z. Cai, Y. Wang, H.-H. Wang, P. Wang*, Z. Nie*. Spatially reprogramed receptor organization to switch cell behavior using a DNA origami-templated aptamer nanoarray. Nano Lett., 2022, 22, 8445-8454.

[8]J. Zhang, H. Li, B. Lin, X. Luo, P. Yin, T. Yi, B. Xue, X.-L. Zhang, H. Zhu, Z. Nie*. Development of near-infrared nucleic acid mimics of fluorescent proteins for in vivo imaging of viral RNA with turn-on fluorescence. J. Am. Chem. Soc., 2021, 143, 19317-19329.

[9]K. Shi, S. Xie, R. Tian, S. Wang, Q. Lu, D. Gao, C. Lei, H. Zhu, Z. Nie*. A CRISPR-Cas autocatalysis-driven feedback amplification network for supersensitive DNA diagnostics. Science Advances, 2021, 7, eabc7802.

[10]H. Li, J. Gao, L. Cao, X. Xie, J. Fan, H. Wang, H.-H. Wang*, Z. Nie*. A DNA molecular robot that autonomously walks on the cell membrane to drive cell motility. Angew. Chem. Int. Ed., 2021, 60, 26087-26095. (Very Important Paper, Inside Back Cover)

[11]J. Zhang, Z. Qiu, J. Fan, F. He, W. Kang, S. Yang, H.-H. Wang*, J. Huang*, Z. Nie*. Scan and Unlock: A programmable DNA molecular automaton for cell-selective activation ligand-based signaling. Angew. Chem. Int. Ed., 2021, 60, 6733-6743. (Hot Paper)

[12]X. Zhu, R. Tang, S Wang, X. Chen, J. Hu, C. Lei, Y. Huang, H. Wang, Z. Nie*, S. Yao. Protein@inorganic nanodumpling system for high-loading protein delivery with activatable fluorescence and magnetic resonance bimodal imaging capabilities, ACS Nano, 2020, 14, 2172-2182.

[13]X. Luo, B. Xue, G. Feng, J. Zhang, B. Lin, P. Zeng, H. Li, H. Yi, X.-L. Zhang, H. Zhu*, Z. Nie*.Lighting up the native viral RNA genome with a fluorogenic probe for the live-cell visualization of virus infection. J. Am. Chem. Soc., 2019, 141, 5182-5191.

[14]G. Feng, X. Luo, X. Lu, S. Xie, L. Deng, W. Kang, F. He, J. Zhang, C. Lei*, B, Lin, Y. Huang, Z. Nie*, S. Yao. Engineering of nucleic acids and synthetic cofactors as holo sensors for probing signaling molecules in the cellular membrane microenvironment.Angew. Chem. Int. Ed., 2019, 58, 6590-6594. (Very Important Paper, Back Cover)

[15]M. Wang, F. He, H. Li, S.H. Yang, J. Zhang, P. Ghosh, H.-H. Wang*, Z. Nie*. Near-infrared light-activated DNA-agonist nanodevice for nongenetically and remotely controlled cellular signaling and behaviors in live animals. Nano Lett., 2019, 19, 2603-2613.

[16]H. Li, M. Wang, T. Shi, S. Yang, J. Zhang, H.-H. Wang*, Z. Nie*. A DNA-mediated chemically induced dimerization (D-CID) nanodevice for nongenetic engineering of receptor to control cell behavior. Angew. Chem. Int. Ed., 2018, 57,10226-10230. (Hot paper)

[17]Y. Li, S. Sun, L. Fan, S. Hu, Y. Huang, K. Zhang, Z. Nie*, S. Yao. Peptide logic circuits based on chemoenzymatic ligation for programmable cell apoptosis.Angew. Chem. Int. Ed., 2017, 56, 14888-14892.

[18]Z. Nie*, P. Wang, C. Tian, C. Mao*. Synchronization of two assembly processes to build responsive DNA nanostructures. Angew. Chem. Int. Ed., 2014, 53, 8402-8405.

[19]C. Lei, Y. Huang, Z. Nie*, J. Hu, L. Li, G. Lu, Y. Han, S. Yao. Supercharged fluorescent protein as a versatile probe for homogenous DNA detection and methylation analysis. Angew. Chem. Int. Ed., 2014, 53, 8358-8362. (Hot Paper)

[1]2022，药明康德生命化学研究学者奖

[2]2021，湖南省优秀科技工作者

[3]2020，湖南省优秀研究生导师

[4]2015，中国化学会青年化学奖

[5]2015，卢嘉锡优秀导师奖