吕考升，湖南大学，生命医学交叉研究院，教授，博士生导师，国家海外高层次人才。

联系方式：Lvks@hnu.edu.cn

2024.01 -至今，湖南大学生命医学交叉研究院，教授，博士生导师

2022.06 - 2023.12，南方科技大学，副教授，博士生导师

2014.08 - 2022.05，宾夕法尼亚大学Perelman医学院，博士后、研究助理，合作导师：Wei Tong

2013.11 - 2014.07，芝加哥大学，博士后，合作导师：Lucia Schuger

2007.09 - 2013.07，北京大学，细胞生物学，博士

2003.09 - 2007.07，青岛大学，生物技术，本科

[1]2022国家优秀青年基金 （海外），主持

[2]2023国家自然科学基金面上项目，主持

[3]2023深圳市医学科学院（SMART）一般项目，参与

[4]2024广东省自然科学基金面上项目，主持

[5]2024湖南大学高层次人才启动基金，主持

发表论文：

[1]Kaosheng Lv and Wei Tong. The hidden conformational code. Blood (Accepted), 2023

[2]Kaosheng Lv and Wei Tong. A protein synthesis brake for hematopoietic stem cell maintenance. Genes & Development 36 (15-16), 871-873, 2022.

[3]Kaosheng Lv and Wei Tong. Waking up CML leukemia stem cells for the kill. Blood 139 (5), 647-648, 2022.

[4]Kaosheng Lv*, Jian-Gang Ren*, Xu Han, Jun Gui, Chujie Gong, Wei Tong. Depalmitoylation Rewires FLT3-ITD Signaling and Exacerbates Leukemia Progression. Blood 138 (22), 2244-2255, 2021 *: Co-first author. Notes: Commented on in this issue.

[5]Kaosheng Lv, Chujie Gong, Charles Antony, Xu Han, Jian-Gang Ren, Ryan Donaghy, Ying Cheng, Simone, Pellegrino, Alan J. Warren, Vikram R. Paralkar, and Wei Tong. HectD1controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis. Cell Stem Cell 28 (7), 1275-1290, 2021 Notes: Commented on in this issue.

[6]Lv, Kaosheng; Jiang, Jing; Donaghy, Ryan; Riling, Christopher R; Cheng, Ying; Chandra, Vemika; Langdon, Wallace Y; Kumar, Suresh; Hexner, Elizabeth O; Band, Hamid; Tong, Wei. CBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem cells and myeloid malignancies. Genes & Development 31 (10), 1007-1023, 2017. This paper is in the top 5% of all research outputs scored by Altmetric.

[7]Kaosheng Lv*, Liang Chen*, Yuanjun Li, Zenglong Li, Yingying Liu, Jianguo Chen and Junlin Teng. Trip6 Promotes Dendritic Morphogenesis through Dephosphorylated GRIP1-dependent Myosin VI and F-actin Organization. The Journal of Neuroscience, 35(6): 2559-2571, 2015. *: Co-first author.

[8]Yingying Liu*, Kaosheng Lv*, Zenglong Li, Albert Chang Yu, Jianguo Chen, Junlin Teng. PACSIN1, a Tau-interacting protein, regulates axonal elongation and branching by facilitating microtubule instability. Journal of Biological Chemistry, 1287(47): 39911-24, 2012. *: Co-first author.

[9]Charles Antony, Subin S. George, Justin Blum, Patrick Somers, Chelsea L. Thorsheim, Dexter J. Wu- Corts, Yuxi Ai, Long Gao, Kaosheng Lv, Michel G. Tremblay,Tom Moss, Kai Tan, Jeremy E. Wilusz, Austen R.D. Ganley, Maxim Pimkin, and Vikram R. Paralkar. Control of ribosomal RNA synthesis by hematopoietic transcription factors. Molecular Cell 82 (20), 3826-3839, 2022

[10]You-Wu Dai, Jun-Kai Ma, Rui Jiang, Xiao-Lin Zhan, Si-Ying Chen, Lin-Lin Feng, Qi Zhang, Ting-Bo Liang, Kaosheng Lv, Guan-Jun Yang, Jian-Fei Lu, Jiong Chen, and Xin-Jiang Lu. Meteorin links the bone marrow hypoxic state to hematopoietic stem/progenitor cell mobilization. Cell Reports 40 (12), 111361, 2022

[11]Danielle Minichino, Kaosheng Lv, Niansheng Chu, Wei Tong, Edward M Behrens. BRAF-V600E utilizes posttranscriptional mechanisms to amplify LPS-induced TNFα production in dendritic cells in a mouse model of Langerhans cell histiocytosis. J Leukoc Biol 112(5), 1089-1104, 2022

[12]Longyong Xu, Xia Liu, Fanglue Peng, Weijie Zhang, Liting Zheng, Yao Ding, Tianpeng Gu, Kaosheng Lv, Jin Wang, Andre Catic, Wei Tong, Ling Qi, Daisuke Nakada, Xi Chen. Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions. Nature Cell Biology 22 (10), 1162-1169, 2020.

[13]Ryan Donaghy, Xu Han, Krasimira Rozenova, Kaosheng Lv, Qinqin Jiang, Miriam Doepner, Roger A. Greenberg, Wei Tong. The BRISC deubiquitinating enzyme complex limits hematopoietic stem cell expansion by regulating JAK2 K63-ubiquitination. Blood 133 (14): 1560-1571, 2019.

[14]Joanna Balcerek, Jing Jiang, Yang Li, Qinqin Jiang, Nicholas Holdreith, Brijendra Singh, Vemika Chandra, Kaosheng Lv, Jian-gang Ren, Krasimira Rozenova, Weihua Li, Roger Greenberg, and Tong Wei. Lnk/Sh2b3 Deficiency restores Hematopoietic Stem Cell Function and Genome Integrity in Fanconi Anemia. Nature communications 9 (1), 1-14, 2018.

[15]Jun Gui, Bin Zhao, Kaosheng Lyu, Wei Tong & Serge Y. Fuchs. Downregulation of the IFNAR1 chain of type 1 interferon receptor contributes to the maintenance of the hematopoietic stem cells. Cancer biology & therapy, 18 (7), 534-543, 2017

[16]Michael M. Yue, Kaosheng Lv, Stephen C. Meredith, Jennifer L. Martindale, Myriam Gorospe and Lucia Schuger. Novel RNA-binding Protein P311 Binds Eukaryotic Translation Initiation Factor 3 Subunit (eIF3b) to Promote Translation of Transforming Growth Factor β1-3 (TGF-β 1-3). Journal of Biological Chemistry 289: 33971-33983, 2014.

[1]2024湖南大学“岳麓学者”

[2]2022国家海外高层次人才

[3]2018 The Alan Gewirtz MD Hematologic Malignancies postdoctoral research Award, USA

[4]2016 ASH Abstract Achievement Award, USA