李家昆，教授、博士生导师。主要从事翻译后修饰-硫酸化反应，生物大分子的后期修饰与构效关系的研究。

研究领域：硫酸化反应方法学，翻译后修饰化学生物学

邮箱：jkli@hnu.edu.cn

2009.09–2014.06中国科学技术大学-中科院上海有机所，理学博士

2005.09–2009.07黑龙江大学，理学学士

2019.09–至今湖南大学化学化工学院教授，博士生导师

2015.05–2019.07德国马普煤炭所、哈佛大学，博士后

2014.07–2015.04中国科学院上海有机化学研究所，助理研究员

[1]Zeting Zhang,Pingping Yu,Chunlan Song and Jiakun Li*.Taming sulfate radical for anti-Markovnikov alkene hydrosulfation.J.Am.Chem.Soc.2026,148,6886–6894.

[2]Ye Zheng,Li Huang,Chunlan Song and Jiakun Li*.Late-stage O-sulfation with a bioinspired sulfuryl donor.Nat.Commun.2025,16,6920.

[3]Wei Sheng,Huanhuan Peng,Ben Gao,Chunlan Song and Jiakun Li*.Electrochemical benzylic C–H sulfation beyond the O-sulfonation limitation.Angew.Chem.Int.Ed.2025,e202507048.

[4]Zhen Xia,Ting Deng,Chunlan Song and Jiakun Li*.Decarboxylative sulfation by persulfates.Chem.Sci.2025,16,11568–11573.

[5]Wei Sheng,Huanhuan Peng,Chunlan Song*and Jiakun Li*.Electrochemical decarboxylative sulfation:a mild and efficient method to access organosulfates.J.Org.Chem.2025,90,7682–7687.

[6]Shuaishuai Yue,Ye Zheng,Chunlan Song and Jiakun Li*.More than oxidants:persulfates as efficient sulfonate donors in O-sulfation.CCS Chem.2025,7,1297–1304.

[7]Zhen Xia,Zhongyao Ye,Ting Deng,Ze Tan,Chunlan Song and Jiakun Li*.Benzylic C–H radical sulfation by persulfates.Angew.Chem.Int.Ed.2025,64,e202413847.

[8]Shuaishuai Yue,Guoping Ding,Ye Zheng,Chunlan Song,*Peng Xu,*Biao Yu and Jiakun Li*.Dimethyl sulfate and diisopropyl sulfate as practical and versatile O-sulfation reagents.Nat.Commun.2024,15,1861.

[9]Zetao Zhao,Qian Yu,Zhen Xia,Zhongyao Ye,Xuejin Huang,Chunlan Song and Jiakun Li*.Stereospecific C–O sulfation via persulfate-induced 1,4-metallate migration.Nat.Synth.2024,3,1529–1537.

[10]Qian Yu,Donglin Zhou,Pingping Yu,Chunlan Song*,Ze Tan*and Jiakun Li*.Silver-catalyzed decarboxylative nitrooxylation of aliphatic carboxylic acids.Org.Lett.2024,26,5856–5861.

[11]Pingping Yu,Xuejin Huang,Dake Wang,Hong Yi,Chunlan Song*and Jiakun Li*.Electrochemical decarboxylative cross-coupling with nucleophiles.Chem.Eur.J.2024,30,e202402124.

[12]Xuejin Huang,Jianhua Cai,Ye Zheng,Chunlan Song*and Jiakun Li*.Electrochemical-induced 1,3-oxohydroxylation of arylcyclopropanes.Adv.Synth.Catal.2024,366,201–206.

[13]Jianhua Cai,Yuxi Wen,Wei Sheng,Xuejin Huang,Ye Zheng,Chunlan Song*and Jiakun Li*.Electrochemical ring-opening 1,3-dihydroxylation of arylcyclopropanes with H2O.Green Chem.2023,25,6618–6622.

[14]Wei Sheng,Xuejin Huang,Jianhua Cai,Ye Zheng,Yuxi Wen,Chunlan Song*and Jiakun Li*.Electrochemical oxidation enables regioselective 1,3-hydroxyfunctionalization of cyclopropanes.Org.Lett.2023,25,6178–6183.

[15]Qian Yu,Donglin Zhou,Yaoyue Liu,Xuejin Huang,Chunlan Song,*Junjun Ma*and Jiakun Li*.Synthesis of benzylic alcohols by decarboxylative hydroxylation.Org.Lett.2023,25,47–52.

Before HNU:

[16]Jiakun Li,Junting Chen,Ruocheng Sang,Won-Seok Ham,Matthew B.Plutschack,Florian Berger,Sonia Chabbra,Alexander Schnegg,Christophe Genicot and Tobias Ritter*.Photoredox catalysis with aryl sulfonium salts enables site-selective late-stage fluorination.Nature Chemistry,2020,12,56–62.

[17]Kumiko Yamamoto#,Jiakun Li#,Jeffrey A.O.Garber,Julian D.Rolfes,Gregory B.Boursalian,Jannik C.Borghs,Christophe Genicot,Jérôme Jacq,Maurice van Gastel,Frank Neese and Tobias Ritter*.Palladium-catalysed electrophilic aromatic C–H fluorination.Nature,2018,554,511–514(#equal contribution).

[18]Jiakun Li and Biao Yu*.A Modular Approach to the total synthesis of tunicamycins.Angew.Chem.Int.Ed.2015,54,6618–6621.

[19]Yu Tang#,Jiakun Li#,Yugen Zhu,Yao Li and Biao Yu*.Mechanistic Insights into the Gold(I)-Catalyzed Activation of Glycosyl ortho-Alkynylbenzoates for Glycosidation.J.Am.Chem.Soc.2013,135,18396–18405(#equal contribution).