楚霞，湖南大学化学化工学院教授，博士生导师，化学生物传感与计量学国家重点实验室副主任。发表通讯作者SCI源刊论文百余篇，他引4000余次，单篇最高他引342次，包括Sci. Adv., J. Am. Chem. Soc.，Angew. Chem. Int. Ed.，Anal. Chem.等。承担主持了多项国家自然科学基金项目，包括国家自然科学基金重大项目，国家科技部重大研发计划项目等。湖南省优秀博士毕业论文指导教师，培养的博士生1人获“博士后创新人才支持计划”。

2022.01 -至今，湖南大学，化学化工学院党委副书记

2017.01 - 2021.12，湖南大学，化学生物传感与计量学国家重点实验室副主任

2006.01 -至今，湖南大学，教授

2005.07- 2005.12，湖南师范大学，教授

2000.07 -2005.07，湖南师范大学，副教授

1999.07-2000.07，湖南师范大学，讲师

1996.09 - 1999.06，湖南大学，分析化学，研究生/博士

1993.09 - 1996.06，湖南大学，分析化学，研究生/硕士

1989.09 - 1993.06，湖南大学，分析化学，本科/学士

[1]国家自然科学基金重大项目子课题，21991080，2019/01-2024/12，520万，主持

[2]国家重点研发计划子课题，2018YFA0902301，2019/07-2024/06，650万，主持

[3]第四批国家“WR计划”科技创新领军人才，SQ2018RA2D200124，2019/09-2122/06，100万，主持

[4]国家自然科学基金国家杰出青年基金项目，21525522，2016/01-2020/12，400万，主持

[5]国家自然科学基金面上项目，21275045，2013/01-2016/12，80万，主持

[6]中华人民共和国教育部新世纪优秀人才支持计划，NCET-11-0121，2012/01-2014/12，50万，主持

[7]湖南省自然科学基金湖南省杰出青年基金项目，12JJ1004，2012/01-2014/12，30万，主持

发表论文：

[1]Ruixi Peng, Qian Huang, Li Wang, Gongxi Qiao, Xiangrong Huang, Jianhui Jiang, and Xia Chu*, G-Quadruplex RNA Based PROTAC Enables Targeted Degradation of RNA Binding Protein FMRP for Tumor Immunotherapy, Angewandte Chemie International Edition, 2024, 63, e202402715.

[2]Gongxi Qiao, Shenglin Li, Xumin Pan, Ping Xie, Ruixi Peng,Xiangrong Huang, Mengyun He, Jianhui Jiang, Xia Chu*, Surgical tumor–derived nanoplatform targets tumor-associated macrophage for personalized postsurgical cancer immunotherapy, Science Advances, 2024, 10, eadk7955.

[3]Kaiji Wei, Yu Xu, Cunpeng Nie, Qiaomei Wei, Ping Xie, Tingting Chen*, Jianhui Jiang, and Xia Chu*, A Multifunctional Peptide Nucleic Acid/Peptide Copolymer-Based Dual-Mode Biosensor with Macrophage-Hitchhiking for Enhanced Tumor Imaging and Urinalysis, Journal of the American Chemical Society, 2024, 146, 33075-33083.

[4]Cunpeng Nie, Tianran Ma, Jingxuan Ye, Mengyun He, Tong Zhang, Kaiji Wei, Jianhui Jiang, Xia Chu*, A STING agonist-loaded bispecific nanobioconjugate modulates macrophage immune responses to enhance antitumor immunotherapy, Chemical Engineering Journal, 2024, 485, 149901.

[5]Tong Zhang, Lan Zhang, Xiangrong Huang, Cunpeng Nie, Mengyun He, Tingting Chen, Jianhui Jiang, Xia Chu*, Dual nanoparticle immunostimulant hydrogel for synergistic combating “Cold” tumor, Chemical Engineering Journal, 2024, 490, 151663.

[6]Xiangrong Huang, Ziqiong Yi, Tong Zhang, Mengyun He, Cunpeng Nie, Tingting Chen, Jianhui Jiang, Xia Chu*, Feature-Enhanced Artificial Neutrophils for Dual-Modal MR/NIR Imaging-Guided Cancer Therapy, Chemical Engineering Journal, 2024, 495, 153436.

[7]Cunpeng Nie, Jingxuan Ye, Jian-Hui Jiang, Xia Chu*, DNA nanodevice as a multi-module co-delivery platform for combination cancer immunotherapy, Journal of Colloid and Interface Science, 2024, 667, 1-11.

[8]Kaiji Wei, Mengyun He, Juan Zhang, Chuan Zhao, Cunpeng Nie, Tong Zhang, Yi Liu,Tingting Chen*,Jianhui Jiang, Xia Chu*, A DNA logic circuit equipped with a biological amplifier loaded into biomimetic ZIF-8 nanoparticles enables accurate identification of specific cancers in vivo, Angewandte Chemie International Edition, 2023, 62, e202307025.

[9]Yi Liu, Mengyun He,Yi Yuan, Cunpeng Nie, Kaiji Wei, Tong Zhang, Tingting Chen, Xia Chu*, Neutrophil-membrane-coated biomineralized metal−organic framework nanoparticles for atherosclerosis treatment by targeting gene silencing, ACS Nano, 2023, 17, 7721.

[10]Gongxi Qiao, Xuming Pan, Mengyun He, Ruixi Peng, Xiangrong Huang, Cunpeng Nie,Jianhui Jiang, Xia Chu*, An ultrathin Zn-based layered double hydroxides augment degradation of mutant p53 to improve tumor therapy, Chemical Engineering Journal, 2023, 475, 146449.

[11]Chuan Zhao, Lan Zhang, Yanlei Hu, Cunpeng Nie, Ting-Ting Chen*, Xia Chu*, Simultaneous imaging and visualizing the association of survivinmRNA and telomerase in living cells by using a dual-color encoded DNA nanomachine, Analytical Chemistry, 2023, 95, 1498.

[12]Dan-Dan Wang, Juan Zhang, Qiao-Qin Yu, Ke Zhang, Ting-Ting Chen*, Xia Chu*, Biomineralized zeolitic imidazolate framework‑8 nanoparticles enable polymerase-driven DNA biocomputing for reliable cell identification, Analytical Chemistry, 2022, 94, 4794.

[13]Ke Zhang, Xiayun Le, Qiaoqin Yu, Juan Zhang, Dandan Wang,Tingting Chen*, Xia Chu*, Biomineralized zeolitic imidazolate framework-8 nanoparticles enable polymerase/endonuclease synergetic amplification reaction in living cells for sensitive microRNA imaging, Chemical Communication, 2021, 57, 8472.

[14]Mengyun He, Pei Yu, Yanlei Hu, Juan Zhang, Manman He, Cunpeng Nie, Xia Chu*, Erythrocyte-membrane-enveloped biomineralized metal−organicframework nanoparticles enable intravenous glucose-responsiveinsulin delivery, ACS Applied Materials & Interfaces, 2021, 13, 19648.

[15]Manman He, Mengyun He, Cunpeng Nie, Jintao Yi, Juan Zhang, Tingting Chen, Xia Chu*, mRNA-activated multifunctional dnazyme nanotweezer for intracellular mrna sensing and gene therapy, ACS Applied Materials & Interfaces, 2021, 13, 8015.

[16]Cunpeng Nie, Yanlei Hu, Jintao Yi, Chang Liu, Juan Zhang, Manman He, Mengyun He, Tingting Chen, Xia Chu*,Aptamer-Functionalized DNA Origami for Targeted Codelivery of Antisense Oligonucleotides and Doxorubicin to Enhance Therapy in Drug-Resistant Cancer Cells, Qingshan Pan, ACS Applied Materials & Interfaces, 2020, 12, 400.

[17]Cunpeng Nie, Ximing Chu, Qingshan Pan, Juan Zhang, Yanlei Hu, Jintao Yi, Manman He, Mengyun He, Tingting Chen, Xia Chu*, Engineering a Biodegradable Nanocarrier for Enhancing the Response of T98G Cells to Temozolomide, ACS Applied Materials & Interfaces, 2020, 3, 3337.

[18]Juan Zhang, Mengyun He, Cunpeng Nie, Manman He, Qingshan Pan, Chang Liu, Yanlei Hu, Tingting Chen, Xia Chu*, Biomineralized metal–organic framework nanoparticles enable a primer exchange reaction based on DNA machine to work in living cells for imaging and gene therapy, Chemical Science, 2020, 11, 7092.

[19]Yanlei Hu, Ximing Chu, Ting-ting Chen, Qingshan Pan, Chang Liu, Jintao Yi, Xia Chu*,Improving resolving ability of expansion microscopy by varying crosslinker concentration, Chemical Communications, 2020, 56, 4176.

[20]Chang Liu, Yanlei Hu, Qingshan Pan, Jintao Yi, Juan Zhang, Manman He, Mengyun He, Cunpeng Nie, Tingting Chen*, Xia Chu*, A photocontrolled and self-powered bipedal DNA walking machine for intracellular microRNA imaging, Chemical Communication, 2020, 56, 3496.

[21]Namin Hu, Yafang Wang, Chang Liu, Manman He, Cunpeng Nie, Juan Zhang, Qiaoqin Yu, Chuan Zhao, Tingting Chen*, Xia Chu*, An enzyme-initiated DNAzyme motor for RNase H activity imaging in living cell, Chemical Communication, 2020, 56, 639.

[22]Jin-Tao Yi, Qing-Shan Pan, Chang Liu, Yan-Lei Hu, Ting-Ting Chen*, Xia Chu*, An intelligent nanodevice based on the synergistic effect of telomerase-triggered photodynamic therapy and gene-silencing for precise cancer cell therapy, Nanoscale, 2020, 12, 10380.

[23]Yu-Jie Zhou, Yuan-Hui Wan, Cun-Peng Nie, Juan Zhang, Ting-Ting Chen*, Xia Chu*, Molecular switching of a self-assembled 3D DNAnanomachine for spatiotemporal ph mapping in living cells, Analytical Chemistry, 2019, 91, 10366.

[24]Juan Zhang, Mengyun He, Cunpeng Nie, Manman He, Qingshan Pan, Chang Liu, Yanlei Hu, Jintao Yi,Tingting Chen*, Xia Chu*, Biomineralized metal−organic framework nanoparticles enable enzymatic rolling circle amplification in living cells for ultrasensitive microRNA imaging, Analytical Chemistry, 2019, 91,9049.

[25]Chang Liu, Yanlei Hu, Qingshan Pan, Jintao Yi, Juan Zhang, Manman He, Mengyun He,Tingting Chen*, Xia Chu*, A microRNA-triggered self-powered DNAzyme walker operating in livingcells. Biosensors and Bioelectronics, 2019, 136, 31.

[26]Yuan-Hui Wan, Yu-Jie Zhou, Ke-Jing Xiao, Cun-Peng Nie, Juan Zhang, Chang Liu, Ting-Ting Chen*, Xia Chu*, Target-assisted self-cleavage DNAzyme probes for multicolor simultaneous imaging of tumor-related microRNAs with signal amplification, Chemical Communication, 2019, 2019, 55, 3278.

[27]Ting-Ting Chen, Jin-Tao Yi, Yan-Yan Zhao, Xia Chu*, Biomineralized metal−organic framework nanoparticles enable intracellular delivery and endo-lysosomal release of native active proteins, Journal of the American Chemical Society, 2018, 140, 9912.

[28]Qing-Shan Pan,Ting-Ting Chen,Cun-Peng Nie, Jin-Tao Yi, Chang Liu, Yan-Lei Hu, Xia Chu*, In SituSynthesis of Ultrathin ZIF8 Film-Coated MSNs for Codelivering Bcl 2 siRNA and Doxorubicin to Enhance Chemotherapeutic Efficacy in Drug-Resistant Cancer Cells, ACS Applied Materials & Interfaces, 2018, 10, 33070.

[29]Jin-Tao Yi, Ting-Ting Chen, Jia Huo*, and Xia Chu*, Nanoscale zeolitic imidazolate framework-8 for ratiometric fluorescence imaging of MicroRNA in living cells, Analytical Chemistry, 2017, 89, 12351.

[30]Yao Cen, Wen-Jing Deng, Yuan Yang, Ru-Qin Yu*, Xia Chu*, A core-shell-shell multifunctional nanoplatform for intracellular tumor-related mrnas imaging and near-infrared light triggered photodynamic-photothermal synergistic therapy, Analytical Chemistry, 2017, 89, 10321.

[31]Yao Cen, Yuan Yang, Ru-Qin Yu, Ting-Ting Chen*, Xia Chu*, A cobalt oxyhydroxide nanoflake-based nanoprobe for the sensitive fluorescence detection of T4 polynucleotide kinase activity and inhibition, Nanoscale, 2016,8, 8202.

[32]Xiang-Juan Kong, Shuang Wu, Yao Cen, Ru-Qin Yu, Xia Chu*, "Light-up" sensing of human 8-oxoguanine DNA glycosylase activity by target-induced auto-catalytic DNAzyme-generated rolling circle amplification, Biosensors & Bioelectronics, 2016, 79, 679.

[33]Shuang Wu, Xiang-Juan Kong, Yao Cen, Jing Yuan, Ru-Qin Yu and Xia Chu*, Fabrication of a LRET-based upconverting hybrid nanocomposite for turn-on sensing of H2O2 and glucose, Nanoscale, 2016, 8, 8939.

[34]Xiang-Juan Kong, Shuang Wu, Ting-Ting Chen*, Ru-Qin Yu and Xia Chu*, MnO2-induced synthesis of fluorescent polydopamine nanoparticles for reduced glutathione sensing in human whole blood, Nanoscale, 2016, 8, 15604.

[35]Ting-Ting Chen, Xue Tian, Chen-Li wei Liu, Jia Ge, Xia Chu*, and Yingfu Li, Fluorescence Activation Imaging of Cytochrome c Released from Mitochondria Using Aptameric Nanosensor, Journal of the American Chemical Society, 2015, 137, 982.

[36]Jing Yuan, Yao Cen, Xiang-Juan Kong, Shuang Wu, Chen-Liwei Liu, Ru-Qin Yu, and Xia Chu*, MnO2 Nanosheet-Modified Upconversion Nanosystem for Sensitive Turn-On Fluorescence Detection of H2O2 and Glucose in Blood, ACS Applied Materials & Interfaces, 2015, 7, 10548.

[37]Shuang Wu, Xiang-Juan Kong, Yao Cen, Ru-Qin Yu and Xia Chu*, Phosphorylation-induced formation of a cytochrome c-peptide complex: a novel fluorescent sensing platform for protein kinase assay, Chemical Communications, 2015, 52, 776.

[38]Yao Cen, Jun Tang, Xiang-Juan Kong, Shuang Wu, Jing Yuan, Ru-Qin Yu and Xia Chu*, A cobalt oxyhydroxide-modified upconversion nanosystem for sensitive fluorescence sensing of ascorbic acid in human plasma, Nanoscale, 2015, 7, 13951.

[39]Jia Ge, En-Cai Ou, Ru-Qin Yu * and Xia Chu*, A novel aptameric nanobiosensor based on the self-assembled DNA–MoS2 nanosheet architecture for biomolecule detection, Journal of Materials Chemistry B, 2014, 2, 625.

[40]Yao Cen, Yan-Mei Wu, Xiang-Juan Kong, Shuang Wu, Ru-Qin Yu, and Xia Chu*, Phospholipid-Modified Upconversion Nanoprobe for Ratiometric Fluorescence Detection and Imaging of Phospholipase D in Cell Lysate and in Living Cells, Analytical Chemistry, 2014, 86, 7119.

[41]Jia Ge, Liang-Liang Zhang, Si-Jia Liu, Ru-Qin Yu, and Xia Chu*, A Highly Sensitive Target-Primed Rolling Circle Amplification (TPRCA) Method for Fluorescent in Situ Hybridization Detection of MicroRNA in Tumor Cells, Analytical Chemistry, 2014, 86, 1808.

[42]Yan-Mei Wu, Yao Cen, Li-Jiao Huang, Ru-Qin Yu and Xia Chu*, Upconversion fluorescence resonance energy transfer biosensor for sensitive detection of human immunodeficiency virus antibodies in human serum, Chemical Communications, 2014, 50, 4759.

[43]Jia Ge, Li-Juan Tang, Qiang Xi, Xi-Ping Li, Ru-Qin Yu*, Jian-Hui Jiang and Xia Chu*, A WS2 nanosheet based sensing platform for highly sensitive detection of T4 polynucleotide kinase and its inhibitors, Nanoscale, 2014, 6, 6866.

[44]Jia Ge, Zhi-Mei Huang, Qiang Xi, Ru-Qin Yu, Jian-Hui Jiang and Xia Chu*, A novel graphene oxide based fluorescent nanosensing strategy with hybridization chain reaction signal amplification for highly sensitive biothiol detection, Chemical Communications, 2014, 50, 11879.

[45]Ting-Ting Chen, Yi-Hui Hu, Yao Cen, Xia Chu* and Yi Lu, A Dual-Emission Fluorescent Nanocomplex of Gold-Cluster Decorated Silica Particles for Live Cell Imaging of Highly Reactive Oxygen Species, Journal of the American Chemical Society, 2013, 135, 11595.

[46]Hai-Bo Wang, Ting-Ting Chen, Shuang Wu, Xia Chu*, Ru-Qin Yu, A Novel Biosensing Strategy for Screening G-quadruplex Ligands Based on Graphene Oxide Sheets, Biosensors and Bioelectronics, 2012, 34, 88.

[47]Hai-Bo Wang, Shuang Wu, Xia Chu* and Ru-Qin Yu, A sensitive fluorescence strategy for telomerase detection in cancer cells based on T7 exonuclease-assisted target recycling amplification, 2012, Chemical Communications, 2012, 48, 5916.

[48]Hai-Bo Wang, Qing Zhang, Xia Chu*, Ting-Ting Chen, Jia Ge, Ru-Qin Yu, Graphene Oxide-Peptide Conjugate as Intracellular Protease Sensor for Caspase-3 Activation Imaging in Live Cells, Angewandte Chemie International Edition, 2011, 50, 7065.