主要开展多肽药物与载体的基础应用研究：提出了多肽药物结构设计的新理论，阐释了树状/手性多肽药物的设计原理、构效关系和药理药效机制；建立了仿生多肽载体的构筑新方法，发展了可感知与突破多重生理病理屏障的活性分子靶向递送系统；发掘了多肽增效药物治疗的新策略，推动了从干预肿瘤生物学机制向重塑病理微环境的治疗模式转变，为治疗耐药性恶性肿瘤、病原微生物感染提供了新思路

以通讯作者在Nature Communications、Journal of the American Chemical Society、Angewandte Chemie International Edition、Advanced Materials、Advanced Functional Materials、ACS Nano等国际重要期刊发表论文40余篇；已授权生物医药类国家发明专利16项

主持国家自然科学基金重大研究计划、面上项目、青年基金等科研项目；主持湖南省重点研发计划、杰 青/优秀青年基金、科技创新人才项目等项目

受邀在中国药学大会、中国药物制剂大会、中国材料大会、中国生物材料大会、中国生物物理大会等进行邀请报告20余次

湖南大学青年教工示范岗、优秀共产党员、优秀教师奖、教学优秀奖、优秀教师新人奖、优秀毕业生指导教师等

联系方式：xianghui.xu@hotmail.com; xianghui.xu@hnu.edu.cn

2019.08-至今，湖南大学，生物学院教授

2018.07-2019.07，美国威斯康辛大学麦迪逊分校，生物医学工程系，Visiting Professor

2017.07-2018.06，南京工业大学，材料科学与工程学院，教授

2015.09-2017.06，四川大学，国家生物医学材料工程技术研究中心，副教授

2014.07-2015.08，四川大学，国家生物医学材料工程技术研究中心，助理教授

2009.9-2014.6，四川大学，高分子化学与物理，理学博士

2005.9-2009.6，北京化工大学，生物功能材料，工学学士

[1]国家自然科学基金，面上项目，2023-01至2026-12，主持

[2]国家自然科学基金，面上项目，2021-01至2024-12，主持

[3]国家自然科学基金，重大研究计划，2020-01至2022-12，主持

[4]国家自然科学基金，面上项目，2017-01至2020-12，主持

[5]国家自然科学基金，青年基金项目，2016-01至2018-12，主持

[6]湖南省自然科学基金，青年基金A类项目，2026-1至2028-12，主持

[7]湖南省重点研发计划，生物与新药创制领域，2022-01至2024-12，主持

[8]湖南省自然科学基金，优秀青年基金项目，2021-01至2023-12，主持

[9]湖南省科技创新人才计划项目，2021-01至2023-12,主持

科研著作：

[1]主编，《纳米生物医药学》，化学工业出版社，十四五规划教材，2025

[2]参编，《有机化学》（撰写独立章节），高等教育出版社，国家规划教材，2025

[3]参编，《分子生物药剂学》（撰写独立章节），化学工业出版社，全国药学类统编教材，2022

[4]参编，《Gene Delivery》（撰写独立章节），Nature Springer出版集团，2022

发表论文：

[1]Kefurong Deng, Dongzhe Zou, Zenan Zeng, Beiling Guo, Wensheng Gong, Yini Xu, Yachao Li, Xianghui Xu*. Chiral Peptidoglycan Mimics Target Bacterial Wall Biosynthesis for Pathogen Intervention. Nature Communications 2026, 17, 3258. (IF=15.6；第一作者为博士研究生邓柯芙蓉，获国家奖学金等荣誉)

[2]Yiming Liu, Yachao Li, Wensheng Gong, Dongzhe Zou, Beiling Guo, Zenan Zeng, Xiaoxiao Li, Yini Xu, Xianghui Xu*. An Immune Nanoenhancer Revitalizes Chemotherapeutics to Tailor Tumor‐Derived dsDNA for Anticancer Immunoengineering. Advanced Materials 2026, 38, e16524. (IF=26.8；第一作者为硕士研究生刘奕鸣)

[3]Zhaofeng Wang, Dongzhe Zou, Beiling Guo, Wensheng Gong, Xiaoxiao Li, Zenan Zeng, Dan Zhu, Shilu Ye, Xin Liu, Yiming Liu, Yachao Li, Xianghui Xu*. A Bifunctional Molecular Adaptor Drives Immune Cell–Hitchhiked Delivery of Protein Therapeutics, Journal of Controlled Release 2026, 396, 115037. (IF=12.4；第一作者为硕士研究生王召峰)

[4]Dongzhe Zou, Kefurong Deng, Zenan Zeng, Wensheng Gong, Beiling Guo, Yiming Liu, Yuxin Xie, Yachao Li, Xianghui Xu*. A Bioinspired Lipopeptide Surmounts Therapeutic Dilemmas of Gram-Positive and Gram-Negative Polymicrobial Infection. Journal of the American Chemical Society 2025, 147, 36339. (IF=15.6；第一作者为博士研究生邹东哲，获中国科协青年人才托举工程（博士生专项）、国家奖学金等荣誉，立项省自然科学基金项目)

[5]Jiahao Xu, Dongzhe Zou, Enyu Dong, Xingyu Jiang, Shuo Xu, Yusheng Xiao, Wensheng Gong, Yini Xu, Zenan Zeng, Kefurong Deng, Yachao Li*, Xianghui Xu*. Biomedical Engineering on Smart Polymeric Nanoparticle–Hydrogel Platforms for Efficient Antibiotic Delivery against Bacterial-Infected Wounds. ACS Biomaterials Science & Engineering 2025, 11, 4166. (IF=5.5；第一作者为本科生徐佳豪，获2025年“互联网+”创新创业大赛湖南省金奖、全国生命科学竞赛湖南省一等奖/全国二等奖）

[6]Jin Yang, Zenan Zeng, Yiming Liu, Yachao Li, Xianghui Xu*. Developing bioinspired delivery systems for enhanced tumor penetration of macromolecular drugs. Journal of Controlled Release 2025, 383, 113845. (IF=11.5；第一作者为杨锦博士，获国家自然科学基金青年基金、国家博士后特别资助）

[7]Zenan Zeng, Yachao Li, Kefurong Deng, Dongzhe Zou, Liguo Liu, Beiling Guo, Yiming Liu, Cheng Shen, Xiaoyu Liang, Xianghui Xu*. Thermal-Cascade Multifunctional Therapeutic Systems for Remotely-Controlled Synergistic Treatment of Drug-Resistant Bacterial Infections. Advanced Functional Materials 2024, 34, 2311315. (IF=19.9；第一作者为博士研究生曾泽南，获中国科协青年人才托举工程（博士生专项）、国家奖学金等荣誉）

[8]Xiaoyu Liang, Yachao Li*, Beiling Guo, Zenan Zeng, Kefurong Deng, Dongzhe Zou, Yuxin Xie, Yini Xu, Cheng Shen, Xianghui Xu*. Inherent Tumor Microenvironment-Reversing Hydrogels: Potentiating Molecular Therapy Efficacy against Drug-Resistant Tumors. Advanced Functional Materials 2024, 34, 2314772. (IF=19.9；第一作者为硕士研究生梁晓钰，获湖南大学优秀硕士学位论文奖)

[9]Liguo Liu, Kefurong Deng, Zenan Zeng, Dongzhe Zou, Yini Xu, Yiming Liu, Beiling Guo, Yachao Li, Xianghui Xu*. Interrupting Antibiotic Resistance Transmission via Natural Product-Embedded Lipopeptide–Polymeric Nanoblockers. ACS Materials Letters 2024, 6, 4461. (IF=9.9；第一作者为硕士研究生刘立果)

[10]Cheng Shen, Yachao Li*, Zenan Zeng, Yiming Liu, Yini Xu, Kefurong Deng, Beiling Guo, Dongzhe Zou, Liguo Liu, Xiaoyu Liang, Xianghui Xu*. Systemic Administration with Bacteria-Inspired Nanosystems for Targeted Oncolytic Therapy and Antitumor Immunomodulation. ACS Nano 2023, 17, 24, 25638. (IF=18.0；第一作者为硕士研究生沈铖，获湖南大学优秀硕士学位论文奖)

[11]Yachao Li, Kefurong Deng, Cheng Shen, Xiaoyu Liang, Zenan Zeng, Liguo Liu, Xianghui Xu*. Enantiomeric Virus-Inspired Oncolytic Particles for Efficient Antitumor Immunotherapy. ACS Nano 2023, 17, 17320. (IF=18.0；第一作者为李亚超博士，获国家博士后创新计划支持、国家自然科学基金支持，现为湖南大学副教授、博导)

[12]Yachao Li, Xiaoyu Liang, Cheng Shen, Kefurong Deng, Zenan Zeng, Beiling Guo, Xianghui Xu*. Bio-Responsive Macromolecular Drug and Small-Molecular Drug Conjugates: Nanoparticulate Prodrugs for Tumor Microenvironment Heterogeneity Management and Therapeutic Response Enhancement. Small 2023, 19, 2301656. (IF=15.2；第一作者为李亚超博士，获国家博士后创新人才支持计划、国家自然科学基金支持，现为湖南大学副教授、博导)

[13]Xiao Zhang, Yachao Li, Yuying Yang, Kefurong Deng, Rongyan Liu, Ruigang Hou, Xianghui Xu*. Molecular and Supramolecular Engineering on Lipopeptide-Based Hole-Punching Nanotoxins to Trigger Multimodal Death of Drug-Resistant Tumors: Apoptosis, Necrosis and Autophagy. Chemical Engineering Journal 2023, 465, 142698. (IF=16.7；第一作者为张晓博士，现为山西医科大学教授、博导)

2012年-2022年10篇代表性论文(通讯或第一作者论文)

[14]Non-Invasive Transdermal Delivery Systems with Deep Tissue Penetrating Ability for Local ROS-Modulating Chemotherapy.Advanced Functional Materials 2022, 32, 2206876. (IF=19.924, Cover Feature)

[15]Nanomedicine Solutions to Intricate Physiological-Pathological Barriers and Molecular Mechanisms of Tumor Multidrug Resistance.Journal of Controlled Release 2020, 323, 483-501 (IF=11.467)

[16]Bioinspired Artificial Tobacco Mosaic Virus with Combined Oncolytic Properties to Completely Destroy Multidrug-Resistant Cancer.Advanced Materials 2020, 32, 1904958 (IF=32.086)

[17]Virion-Like Membrane-Breaking Nanoparticles with Tumor‐Activated Cell‐and‐Tissue Dual‐Penetration Conquer Impermeable Cancer.Advanced Materials 2018, 30, 1707240 (IF=32.086, Cover Feature)

[18]Tumor-Adapting and Tumor-Remodeling AuNR@ Dendrimer-Assembly Nanohybrids Overcome Impermeable Multidrug-Resistant Cancer. Materials Horizons 2018, 5, 1047-1057 (IF=15.717, Cover Feature)

[19]Tumor-Specific Multiple Stimuli-Activated Dendrimeric Nanoassemblies with Metabolic Blockade Surmount Chemotherapy Resistance. ACS Nano 2017, 11, 416-429 (IF=18.027)

[20]Bioinspired therapeutic dendrimers as efficient peptide drugs based on supramolecular interactions for tumor inhibition. Angewandte Chemie International Edition 2015, 127 (14), 4363-4368 (IF=16.823, Cover Feature)

[21]Virus‐Inspired Mimics Based on Dendritic Lipopeptides for Efficient Tumor‐Specific Infection and Systemic Drug Delivery. Advanced Functional Materials 2015, 25 (33), 5241-5241 (IF=19.924, Cover Feature)

[22]Bio-Inspired Supramolecular Hybrid Dendrimers Self-Assembled from low-generation peptide dendrons for highly efficient gene delivery and biological tracking. ACS Nano 2014, 8, 9255-9264 (IF=18.027)

[23]Smart Nanovehicles Based on pH-Triggered Disassembly of Supramolecular Peptide‐Amphiphiles for Efficient Intracellular Drug Delivery. Small 2014, 10, 1133-1140 (IF=15.153, Cover Feature)

[24]Cooperative Hierarchical Self-Assembly of Peptide Dendrimers and Linear Polypeptides into Nanoarchitectures Mimicking Viral Capsids. Angewandte Chemie International Edition 2012, 51, 3130-3133 (IF=16.823)